https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12764 Sat 24 Mar 2018 08:18:20 AEDT ]]> Effect of amitriptyline and escitalopram on functional dyspepsia: a multicenter, randomized controlled study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27609 3-fold more likely to report adequate relief than those given placebo (odds ratio = 3.1; 95% confidence interval: 1.1-9.0). Neither amitriptyline nor escitalopram appeared to affect GE or meal-induced satiety after the 10-week period in any group. Subjects with delayed GE were less likely to report adequate relief than subjects with normal GE (odds ratio = 0.4; 95% confidence interval: 0.2-0.8). Both antidepressants improved overall quality of life. Conclusions Amitriptyline, but not escitalopram, appears to benefit some patients with FD, particularly those with ulcer-like (painful) FD. Patients with delayed GE do not respond to these drugs.]]> Sat 24 Mar 2018 07:39:41 AEDT ]]> Multi-dimensional gastrointestinal symptom severity index: validation of a brief GI symptom assessment tool https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28111 a priori hypothesized six-factor measurement model (X2(428) = 1462.98; P<0.001; GFI = .88; RMSEA = .051). Conclusion: The GISSI demonstrated good to excellent psychometric properties and provided multi-dimensional scaling of prominent GI symptom clusters. Further validation may provide an efficient, valid, and reliable measure of patient-reported clinical outcomes.]]> Sat 24 Mar 2018 07:25:00 AEDT ]]>